CBD or cannabidiol is the main active compound in hemp and unlike THC, it is not psychoactive, so it doesn’t make you high., Inside the human body there’s the endocannabinoid system, with receptors spread throughout the brain and body. THC activates the CB1 and CB2 receptors, while CBD does not directly stimulate these receptors. The CB1 and CB2 receptors
Cannabinoid receptors are involved in a series of processes inside the human body, including the regulation of mood, pain sensation, appetite and memory.
These receptors can be activated by endocannabinoids (produced by the human body) as well as by plant cannabinoids (like those found in hemp or cannabis), and they’re grouped in two main categories: CB1 and CB2.
CB1 receptors are found mostly in the central nervous system, and in smaller numbers in the liver, kidneys and lungs, while CB2 receptors are part of the immune system and found in the hematopoietic blood cells as well.
CB1 play a role in the production and release of neurotransmitters, cannabis products that exert psychoactive effects stimulating these receptors.
At the same time, CB1 receptors are involved in the lipogenesis process that takes place inside the liver, and seem to play a role in the maintenance of homeostasis (body’s internal equilibrium). Various studies suggest that CB1 also influence pleasure, concentration and appetite, memory and pain tolerance.
CB2 receptors on the other hand affect the immune system, being involved in a variety of functions like immune suppression or apoptosis (programmed cell death).
Studies suggest that CB2 modulate the pain sensation and could play a role in various diseases, from liver and kidney problems to neurodegenerative diseases.
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